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We do acknowledge, however, that finding the simplest combination of context-dependent mutations and associated mutational rates that fits the observational data is not necessarily the actual underlying biological process.
To assess genetic mutations and associated somatic anomalies in a series of patients with 46,XY gonadal dysgenesis (GD).
In the Asia-Pacific region, however, evidence of fluoroquinolone mutations and associated treatment failure is emerging.
Because identical mutations were found even in many uncommon strains, gyrase mutations and associated fluoroquinolone resistance alone cannot explain the high prevalence of ribotypes 001 and 027.
From this, a list of putative somatic mutations and associated confidence values is produced, which can be used in downstream analyses.
Database URL: http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/ COSMIC is a repository for somatic mutations and associated phenotype/clinical information, combining data from a number of sources.
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Aside from KRAS further genes of signaling proteins might be affected by oncogenic mutation and associated with resistance to EGFR inhibition.
Detailed knowledge of mutation locus and associated gating abnormalities may help stratify the risk of adverse effects and permit the addition of an anti-epileptic drug with direct sodium channel blocking action for some patients.
This study was designed to characterize the frequency of LKB1 mutations, their relationship to EGFR and KRAS mutations, and their associated clinicopathologic characteristics in Chinese patients.
This paper reviews the key mutations and mechanisms associated with resistance to the nucleos(t)ide analogues approved for clinical use and discuss new targets for drug development.
All included mutations and regions associated with drug resistance mutations are listed in Additional file 1.
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