Sentence examples for mutations and are from inspiring English sources

Since the LAR TNBC cell lines that are sensitive to AR antagonists also harbor highly clonal PIK3CA mutations and are sensitive to PI3K inhibitors [ 3], we hypothesized that combined targeting of AR and PI3K would more effectively induce growth arrest or apoptosis than either agent alone.

These findings broaden the spectrum of ALS-causing mutations and are indispensable for designing optimal strategies of mutational analysis and genetic counseling of ALS for patients of Chinese origin.

Mutations that confer a fitness advantage to the cell are known as driver mutations and are causally related to tumorigenesis.

Epigenetics, as it pertains to biology and toxicology, can be defined as heritable changes in gene expression that do not involve mutations and are propagated without continued stimulus.

Clinicians should now be able to screen newly diagnosed lung cancer patients to see if their tumors carry the EGF receptor mutations and are thus good candidates for Iressa therapy.

This result adds a wrinkle to the already-difficult screening and treatment decisions faced by individuals who know they carry BRCA mutations and are likely to get breast cancer.

Patients with autoimmune lymphoproliferative syndrome or ALPS have Fas mutations and are at high risk for NHL [22].

The knowledge of orthologous genes shared by B. cereus genomes identified the group of genes which evolve by point mutations and are thus suitable for phylogenetic analysis.

However such data are typically available only for a limited number of genes and mutations and are not suitable for genome-wide analysis.

Cord blood cells, compared to other somatic cell types, have unique advantages as donor cells for the production of clinical-grade human iPSCs, since these cells potentially contain less somatic mutations, and are readily available.

These two summary statistics use an outgroup sequence to identify recent intraspecific mutations and are less affected by small sample sizes than test statistics based on mismatch distributions or Fu's FS [41].