Sentence examples for mutations and alteration from inspiring English sources

Computational modeling indicated that a direct relationship exists between βI-tubulin mutations and alteration in the microtubule assembly and dynamic instability in KB-L30 cells and this predicted model was supported by an increased microtubule assembly and reduced microtubule dynamic instability in KB-L30 cells, as shown by Western blot analysis.

The AR itself undergoes gene amplification, point mutations and alteration in splicing leading to constitutively active variants.

IPD is associated with point mutations in the human prion protein gene (PRNP), premature stop codon mutations and alteration in the number of octapeptide repeat insertions (OPRI) in the unstructured region of the N-terminal domain (Mead, 2006).

So just as evolution of species is driven by mutation and selection, cancer evolution is also driven by both oncogenic mutations and alterations in selective pressures, both of which can result from aging and carcinogenic exposures.

It is likely that multiple combinations of transforming mutations and alterations in miRNA expression can contribute to a metastatic phenotype.

Of note, most studies examining FLT3-ITD in cell lines, have introduced the FLT3-ITD mutation into an already transformed cell with existing mutations and alterations.

Because recombination has been implicated in immune evasion, the acquisition of drug-resistance mutations, and alterations of viral co-receptor usage, any attempt towards the successful eradication of HIV-1 requires therapeutic approaches targeting tissue macrophages.

Its mutations and alterations have been found in colorectal and other cancers.

Other mutations and alterations in gene expression in cancer also contribute to aberrant activation of the pathway.

This reflects the nature of cancer heterogeneity in which multiple mutations and alterations generate the cancer phenotype.

Events such as genetics mutations and alterations in the regulation of signal transduction pathways play important roles in the initiation of cancer (Hartwell and Kastan, 1994; Weinberg, 1996).