Sentence examples for mutations and additional from inspiring English sources

The pathogenesis of SM-AHNMD is not well understood; however, combined KIT tyrosine kinase receptor mutations and additional genetic events in myeloid stem cells may have a pathogenic role.

Data will be presented on the mutations and additional sequence changes identified, several of which appear to be ethnic specific, as well as the corresponding clinical phenotype in mutation positive and negative patients.

At the single-cell level, most primary tumors are polyclonal due to punctuated clonal evolution where copy number alterations serve as founder mutations and additional CNVs and/or point mutations occur later in tumor development.

When the RecBCD pathway is inactivated by mutations and additional mutations inactivate the SbcCD and ExoI nucleases, the RecF pathway can also repair DNA double-strand breaks.

A decline in mitochondrial energy production can generate increased ROS, which cause mitochondrial mutations and additional ROS production [ 4, 5].

The coding sequence of uORF2 and 3 was changed using compensatory frameshift mutations and additional site-directed mutagenesis [ 13].

#28 and #29), we identified the presence of a clone possessing both the JAK2 V617F mutation and additional chromosomal lesion(s) associated with AML transformation.

This mutation and additional mutations in iclR and arcB all improve acetate utilization in Cit– cells by increasing flux through the TCA and glyxolyate cycles.

Warren and colleagues identified a P. aeruginosa isolate from a chronic infection that also possessed the S281G mutation and additional isolates in which MutS was truncated at residue 426 [ 11].

(4) The relatively high frequency of multiplets with two or more clustered mutations and an additional mutation at a distal location also argues for a chronocoordinate mutational event plus an independent single mutational event.

The fact that about 7% of lung tumor samples are likely to have c-CBL mutations and an additional 22% are likely to harbor c-CBL-related LOH, makes c-CBL a highly mutated molecule in lung cancer.