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However, prevalence of CFTR mutations among normal and infertile Chinese males is not well investigated.
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There was also a significant difference in the incidence of the TP53 mutation among patients with normal karyotype (1.8%), simple chromosomal abnormalities with one or two changes (0.5%) and CK with three or more abnormalities (58.8%, P<0.0001).
Mutations in normal tissue are stochastic, vary widely among cells and are therefore difficult to detect using standard methods because each change is so rare.
Detecting Somatic Mutations in Normal Cells.
The prevailing mutation theory holds that 3-6 gene mutations convert normal to cancer cells.
Busque, L. et al. Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
High burden and pervasive positive selection of somatic mutations in normal human skin.
"But among normal people it's fine.
Martincorena, I. et al. High burden and pervasive positive selection of somatic mutations in normal human skin.
Martincorena I, Roshan A, Gerstung M et al. High burden and pervasive positive selection of somatic mutations in normal human skin.
Compensatory mutations restored normal telomerase function.
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