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The hemizygous nature of the X will greatly increase selection on recessive mutations, altering the rate and kind of mutational changes.
Kelley, M. R., Kidd, S., Deutsch, W. A. & Young, M. W. Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.
These results demonstrate that genetic mutations altering the BMP signaling pathway in the stromal microenvironment can lead to epithelial tumors in the colon.
A large number of genome-wide association studies have linked missense mutations, mutations altering the amino acid sequence of proteins, with cognitive impairment in humans.
We end by proposing a set of mutations altering the swapping propensities, whose experimental characterization would contribute to refine our in silico derived hypotheses.
Obviously, this hypothesis makes sense in the case of mutations altering the polymerase DnaE.
Similar(32)
These mutations altered the amount of helical content.
The latter finding indicates that these mec-10 mutations alter the ionic selectivity of the transduction channel in vivo.
We used molecular dynamics simulations to assess how these mutations alter the secondary and tertiary structures of human PFN1.
As evolution proceeds, mutations alter the content and size of this primordial genetic material, and we get longer and more elaborated pieces".
This review discusses the recent structural insights and raises the possibility of using modeling for mechanism-based diagnosis of how deleterious mutations alter the integrity of solid tissues.
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