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We have tested mutant HSV-2 in vivo, and show that these mutations alter early chemokine and cytokine production at the mucosa and are associated with reduced mucosal viral replication, but have minimal effects on pathogenicity and acute T-cell responses.
We are particularly interested in how EYA1 mutations alter early ear development and use Xenopus embryos as a model.
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As evolution proceeds, mutations alter the content and size of this primordial genetic material, and we get longer and more elaborated pieces".
Different disease-causing mutations alter the Nav1.4 channel function through distinct mechanisms.
Functional studies revealed these mutations alter APP processing.
experimentally altered early growth through a dietary manipulation.
These mutations altered the amount of helical content.
Most of the FGF17 and IL17RD mutations altered protein function in vitro.
These mutations altered cellular proliferation, apoptosis and anchorage-dependent growth.
Strain CH1 had a point mutation altering one amino acid residue (A41D) in acrR.
Used mutation alters one array value in a chromosome from its initial state.
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