Sentence examples for mutations affects essential from inspiring English sources

In conclusion, we have shown that RC deficiency secondary to the clonal expansion of pathogenic mtDNA mutations affects essential cellular functions in the human colonic epithelium.

Despite proteomic evidence of extensive Ssa phosphorylation and the recent finding that mutation of putative phosphorylation sites affects essential functions (Beltrao et al., 2012), a regulatory role remains to be established.

The non-coding 5'-flanking sequence of a gene may contain regulatory elements such as the promoter that control the expression of that gene, and single-base mutations can affect essential structures for splicing and processing [ 24].

Here we show, that distinct mutations affecting the essential DNA topoisomerase I (TopA) cause glutamate prototrophy of the ccpA mutant.

The budding yeast temperature-sensitive cdc13-1 mutaffectsffecthethessentialal Cdc13 protein that binds telomeric ssDNA in budding yeast (Hartwell et al, 1973).

Splicing mutations are traditionally considered those that affect essential nucleotides of the donor (GT) and the acceptor (AG) sites [ 13], although other intronic and exonic nucleotides are critical for splice site selection [ 14].

Adaptation to a new host allows a massive clonal population growth in which all mutations affecting genes that are not essential for bacterial survival in the new environment are maintained.

Clearly, the MSL-complex has an essential function, as mutations affecting its components are male-specific lethal, and we speculate that this function is to enhance the expression of genes that lack effective feed-back regulation; these seem to be mostly short housekeeping genes.

Primary cilia are essential for vertebrate development, and mutations affecting this organelle underlie a large group of human malformation syndromes, the ciliopathies.

The PIN3 S1A – S3A mutations affect PID-dependent PIN3 polarity changes, which are essential for lateralization of auxin and possibly also for PID-dependent activation of PIN3 auxin transport and they are therefore more severe.

Instead each specific mutant of a specific isoform will have to be addressed as a separate target within the context of how the mutation affects the wild type features essential to Ras function.