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However, mutations affecting various regions covering the whole length of hGRα are increasingly reported in a variety of disease states.
In addition to the isolation of several zebrafish chromatophore mutants that arose spontaneously [12], [13], numerous mutagenesis screens have yielded over 100 mutations affecting various processes in the development of different combinations of the chromatophore types [6], [14] [17].
For example, you demonstrate that constitutive expression of TrAP causes developmental defects reminiscent of mutations affecting various epigenetic modifications.
NS is genetically heterogeneous, being caused by germline mutations affecting various genes implicated in the RAS signaling network.
Some occasional outliers between the two analyses could be due to mutations affecting various other parameters such as cell permeability to the dye, or intracellular structural modifications.
UV-B can influence metabolic processes of plants either through direct damage including DNA damage and protein denaturation, which often cause heritable mutations affecting various metabolic processes or via various regulatory effects.
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In these Mendelian traits, heterozygous germline mutations affect various genes coding for members of the small subfamily of RAS GTPases, signal relay proteins that function as modulators of RAS function, RAS effectors, and downstream signal transducers.
About 10-point mutations in PRNP affecting various codons are known to be associated with GSS.
By comparing the various analyses it could be safely concluded that except P437L and A379V mutations, all other mutations were potentially deleterious affecting various structural aspects of RING2 domain architecture.
Human mtDNA and nDNA mutations causing mitochondrial dysfunction are implicated in a broad spectrum of diseases affecting various tissues like brain, heart, liver, skeletal muscles, etc.
The chicken is the most variable bird (Somes 1988), because there are hundreds of chicken breeds, integrating various mutations affecting body size, reproduction, growth rate, posture, color, feather structure and distribution, comb shape, and behavior.
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