Sentence examples for mutations affecting specific from inspiring English sources

However, the effectiveness of these therapies is compromised by mutations affecting specific genes, controlling and/or regulating apoptotic signaling.

However, the effectiveness of some of these therapies is blunted by mutations affecting specific effectors genes controlling and/or regulating apoptotic signaling, such as epigenetic silencing of caspase 8, downregulation of pro-apoptotic proteins Bax and Apaf-1, as well as upregulation of the anti-apoptotic proteins of the Bcl-2 and IAP families.

This independence probably results from mutations affecting specific molecular pathways.

Mutations affecting specific splicing regulatory elements offer suitable models to better understand their interplay and to devise therapeutic strategies.

However, a detailed examination of gene function and pathways could not be carried out due to the lack of mutations affecting specific steps in the vulval development process.

A recent report in Neural Development shows how a forward genetic screen has enabled the identification of novel mutations affecting specific decision points of thalamocortical axon pathfinding.

It is likely that these mutations affect specific protein protein interactions relevant for the proper functioning of plectin in HDs.

By contrast, there is a very strong correlation between mutations affecting a specific domain of fibrillin-1 and the unique phenotype of stiff skin syndrome (SSS; OMIM 184900) [ 37].

The CNS-specific phenotype shown by the Nde1−/−Lis1+/− mutant suggests that the mutation affects specifically the neural progenitors.

In the cases of mutations affecting rod-specific genes such as rhodopsin, it is unclear how the mutations may cause degeneration of cones.

Vitis vinifera mutations affecting tissue-specific characteristics of grapevine are rare.