Sentence examples for mutations affecting one from inspiring English sources

The α-thalassemias arise from deletions or mutations affecting one or more α-globin genes on chromosome 16, leading to decreased or absent α-globin chain production [ 1, 2].

Additionally, mutations affecting one of the other two members of the MRN complex, MRE11 and RAD50, have been linked to the onset of ataxia-telangiectasia-like disorders [ 194].

Heterozygous point mutations affecting one of several residues in IDH1 (or the corresponding residues in IDH2) are prevalent in gliomas and acute myeloid leukemia (AML) [40].

Mutations affecting one of the paired keratins of specialized epidermis have been found to be the molecular basis for both of these disorders.

They have been shown to be critical for the enzymatic activity of the protein [17,21] and nonsense or frame shift mutations affecting one or both these conserved motifs are predicted to be non-functional [22].

A common feature of the DGC is that mutations affecting one of its components often lead to destabilization of the complex with reduced or altered expression of other DGC-members.

Individual point mutations affect one residue at a time, leading to small change in the surface characteristics of a protein.

Achondroplasia is a form of dwarfism caused by a genetic mutation, affecting one in 20,000 people.

Defects in both axillary shoot formation and organ separation were enhanced by combining rps10b-1 with cuc3, a mutation affecting one of three Arabidopsis NAC transcription factor genes with partially redundant roles in these processes.

The mutation affects one of the invariant residues at the splice acceptor site, as a result of which two aberrant transcripts are produced.

The mu290 mutation affects one of the two nuclear localisation signals (NLSs) in ceh-20, and our analysis demonstrated that this NLS (NLS II, but not NLS I) is essential for correct nuclear localisation in seam cells (Fig. 3B).