Sentence examples for mutations affecting mitochondrial from inspiring English sources

Hence, mutations affecting mitochondrial structure also affect metabolism.

Mutations affecting mitochondrial function have been shown to cause Leber's Hereditary Optic Neuropathy (LHON), MERRF, MELAS, Chronic Progressive External Ophthalmoplegia (CPEO), Kearns-Sayre Syndrome (KSS), and various other pediatric and adult cardiomyopathies.

Notably, aSyn has been recently localized in the MAM, with pathogenic mutations affecting mitochondrial dynamics [ 53].

Mutations affecting mitochondrial genome maintenance were highly represented in sensitive mutants.

Together these data suggest that mutations affecting mitochondrial respiration lengthen life span by increasing ROS levels and HIF-1activity.

Mutations affecting mitochondrial genome maintenance and translation were highly represented in sensitive mutants in either growth phase.

Though both mutations affected mitochondrial ISC enzymes activities and mitochondria ultrastructure, the hFXNI154F mutant presented a more severe phenotype with affected cytosolic and nuclear ISC enzyme activities, mitochondrial iron accumulation and an increased sensitivity to oxidative stress.

Only one mutation affecting mitochondrial fission has been associated with human disease thus far: encephalopathy with optic atrophy caused by the A395D variant of the dynamin-like DRP1 protein (Waterham et al., 2007).

In trying to understand the reasons for these differences, it is worth noting that the seemingly straightforward functional subclassification of PINK1 and Parkin mutations as principally affecting mitochondrial quality control, and Mfn2 and Opa1 mutations as primarily impacting mitochondrial dynamism, may be misleading.

Noncomplementation, during our triage of sfa alleles, was defined as the strong suppression of mtDNA loss from fzo1 ∆ aac2 ∆ cells at a level typical of mutations affecting known mitochondrial division components.

To date, the number of patients identified as harbouring mutations in nuclear genes affecting mitochondrial translation is very limited (Table 1).