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Although mutations affecting inflammatory molecules have been identified in some cases of the syndromes, more than half remain unexplained.
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In a search for a candidate gene affecting inflammatory pathways, among five screened in our patient samples (100 probands with FMS and their parents), we found 10 rare and one common alleles for MEFV, a gene in which various compound heterozygous mutations lead to Familial Mediterranean Fever (FMF).
But what interests him most is homing in on the mutations affecting the cilia.
We hypothesise a higher frequency of mutations affecting smokers.
Mutations affecting the DGC cause muscular dystrophies.
Hence, mutations affecting mitochondrial structure also affect metabolism.
Mutations affecting proline residues commonly affect protein structure/stability.
The silent mutations include synonymous mutations and mutations affecting noncoding DNA.
The disease mechanisms of mutations affecting the α1.α1.
These include mutations affecting the GTPase domain of LRRK2.
Butyrate may affect inflammatory process through the regulation of inflammatory genes (Andoh et al. 1999; Place et al. 2005).
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