To determine whether the mutations affected distinct functional groups, we categorized the affected gene targets by gene ontology (GO) classification.
Importantly, the mutations affect distinct processes required for germline formation.
Our biochemical analyses indicate that specific mutations affect distinct aspects of pk1a protein function that, when compromised, display overlapping phenotypes.
These mutations, which affect distinct residues in CSF3R as compared with CNL, are frequently associated with mutations in the ASXL1 gene and have a poor prognostic impact on overall and acute myeloid leukemia (AML -free survivAML -free
Here we show, that distinct mutations affecting the essential DNA topoisomerase I (TopA) cause glutamate prototrophy of the ccpA mutant.
The possible ways that mutations affecting this protein can cause several distinct neurodegenerative diseases are explored in this Review to highlight the complexity underlying selective vulnerability.
Our surprising finding was that there is no overlap between mutations affecting mating-type and telomeric silencing, suggesting that Rap1 plays distinct roles in silencing at the silent mating-type loci and telomeres.
Mutations affecting the Na+, K+ ATPase alpha subunit have been implicated in at least two distinct human diseases, rapid-onset dystonia Parkinsonism (RDP), and familial hemiplegic migraine (FHM).
-, -, -,,,, Third, that mutations affecting post-translational modification of the CTD profoundly influence phenotype in a wide variety of distinct organisms.
But what interests him most is homing in on the mutations affecting the cilia.
