Sentence examples for mutations affecting cysteine from inspiring English sources

Mutations affecting cysteine residues and the T50M variant were among the first identified in TRAPS.

Importantly, mutations affecting cysteine residues, a characteristic of CADASIL (Chabriat et al., 2009), were absent in the Austrian Stroke Prevention Study cohort.

Missense mutations involving a cysteine residue (either gain or loss) in the EGF repeats is a hallmark for CADASIL mutations in NOTCH3 [ 33], but we did not find any missense mutations affecting cysteine residues in the CCLE data set.

During the preparation of the manuscript, Kornfeld and co-workers (25) reported the analysis of two missense mutations affecting cysteine residues in the Notch-repeat-like domain 2 of the α-subunit.

Pathogenic mutations predominantly affect cysteine residues within individual epidermal growth factor (EGF -like rEGF -like the Notch3 extrepeatslar dofain (Nothe3-ECD) [ 10, 11] leadiNotch3Notch3-extracellularzation andomainmulation in the tunica media of vessel walls [ 10].

There was considerable variation in attack duration with a third of attacks lasting less than a week, shorter attacks were more frequent in patients with low-penetrance SVs, accounting for 40% compared with 26% in patients with mutations affecting T50M or cysteine residues (p<0.05) (figure 1).

In particular, the structure provides an explanation for the observations that, in addition to mutations affecting the conserved cysteine ligands, alterations in the sequence between the two zinc-binding modules or C-terminal to Zn-2 have a profound negative impact on CTD function (Budd and Campbell, 1993; Navas et al, 1995; Dua et al, 1998, 1999).

The strongly reduced nucleotide affinity of IATR-labeled ParM could be due to the larger size of the tetramethylrhodamines, along with the two cysteine mutations affecting the binding.

Interestingly, in the EGF module in the second diad, there are four mutations affecting four of the six cysteines.

The majority of these mutations affected the conserved cysteine residues and could function as a second hit in the transformation process in the female mammary gland [6].

Mapping of mutations affecting pyoverdine production in Pseudomonas aeruginosa.