Moreover, we show that multiple, native, missense point mutations affecting various domains in ~10% of CRC patients may affect PTPRS function, underscoring their significance.
However, mutations affecting various regions covering the whole length of hGRα are increasingly reported in a variety of disease states.
In addition to the isolation of several zebrafish chromatophore mutants that arose spontaneously [12], [13], numerous mutagenesis screens have yielded over 100 mutations affecting various processes in the development of different combinations of the chromatophore types [6], [14] [17].
For example, you demonstrate that constitutive expression of TrAP causes developmental defects reminiscent of mutations affecting various epigenetic modifications.
NS is genetically heterogeneous, being caused by germline mutations affecting various genes implicated in the RAS signaling network.
Some occasional outliers between the two analyses could be due to mutations affecting various other parameters such as cell permeability to the dye, or intracellular structural modifications.
UV-B can influence metabolic processes of plants either through direct damage including DNA damage and protein denaturation, which often cause heritable mutations affecting various metabolic processes or via various regulatory effects.
Importantly, human seizure disorders have been linked to mutations in genes encoding pyruvate carboxylase, and pyruvate dehydrogenase, the two enzymes upstream of citrate synthase, as well as to mutations affecting various steps in the TCA cycle [ 20].
Remarkably, eight different mutations affecting various loop residues were found to suppress the His+ phenotypes conferred by dominant Sui− alleles SUI3-2 and SUI5, including R148A/E, R156A/E, R157A/E, A154R and A155E.
A number of small- and large-scale ENU mutagenesis screens have been carried out, where classical F3 crossing schemes have been employed to identify recessive zygotic mutations affecting various processes (Loosli et al. 2000; Furutani-Seiki et al. 2004).
