Sentence examples for mutations affect epigenetic from inspiring English sources

Exactly how these mutations affect epigenetic reprogramming has yet to be determined, though they are likely pleiotropic, diverse, and dependent on location and type of mutation.

Apart from mutations affecting epigenetic modifiers, other genes are certainly also affected.

Alongside the generally accepted association between sarcomas and mutations in genes encoding key differentiation/proliferation regulators or involved in signaling (e.g. Ras-MAPK, STAT and PI3K), there is increasing evidence of an association with mutations affecting epigenetic factors and of a link between cell transformation and an altered chromatin landscape [ 86].

It is suggested that these mutations may affect epigenetic chromatin states, resulting in a higher basal level of VRN-1 expression [ 19, 26, 40, 41].

Corces-Zimmerman MR, Hong W-J, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission.

For example, you demonstrate that constitutive expression of TrAP causes developmental defects reminiscent of mutations affecting various epigenetic modifications.

Targeted next-generation sequencing for 275 known and investigative cancer genes (of which 41 genes, or 14.9 %, encoded an epigenetic regulator) of 38 treatment-naïve patient melanoma samples revealed that 22.3%% (165 of 740) of all non-silent mutations affected an epigenetic regulator.

However, taken together with a recent report that mutations affecting the epigenetic factor SETD2 are associated with loss of histone H3 lysine 36 tri-methylation (H3K36me3) and increased intron retention in clear cell renal cell carcinoma [ 19], our results suggest that crosstalk between epigenetics and RNA splicing may link a diverse spectrum of mutations to RNA processing defects in cancer.

How activating mutations affect MEK1 regulation and function.

Title How activating mutations affect MEK1 regulation and function.

The lion's share of those mutations affect myosin.