Sentence examples for mutations affect distinct from inspiring English sources

Importantly, the mutations affect distinct processes required for germline formation.

Our biochemical analyses indicate that specific mutations affect distinct aspects of pk1a protein function that, when compromised, display overlapping phenotypes.

To determine whether the mutations affected distinct functional groups, we categorized the affected gene targets by gene ontology (GO) classification.

This variable phenotype is associated with a wide genetic heterogeneity due to various missense mutations affecting distinct functional domains of the nuclear receptor and responsible for impaired glucocorticoid signalling [9].

These mutations, which affect distinct residues in CSF3R as compared with CNL, are frequently associated with mutations in the ASXL1 gene and have a poor prognostic impact on overall and acute myeloid leukemia (AML -free survivAML -free

Mutation in Cdc20 or Cdh1 affect distinct aspects of the cell cycle, and Cdc20 and Cdh1 coimmunoprecipitate with distinct APC target proteins [ 24, 25], indicating that these proteins have non-overlapping functions.

We have used a strategy that combines patterns of epistasis and pleiotropy to derive a large-scale network mapping how mutations in signaling genes interact to affect distinct phenotypes.

Even though the observation that mutations in the same gene can affect distinct clinical phenotypes has been a well-known and studied concept in molecular genetics (13), this avalanche of data resulting from the first era of exome sequencing has revealed novel connections between phenotypes that can help us to better understand the pathobiology of different neurological diseases.

The major hurdles to design effective therapeutic strategies for these diseases are: the genetic heterogeneity (a number of distinct mutations affect numerous individual gene), and the tools to turn off mutated genes are inefficient and difficult to be delivered specifically and efficiently to diseased cells.

To date, more than 210 distinct mutations affect proteins that localize to the M-region.

Indeed, systematic UNC-45 pull-down experiments, which were carried out at different temperatures and using cell lysates from unc-45 m94 unc-45 m94type worms reveandd that the distinct mutations affect the binding of the myosin substrate to different degrees.