Sentence examples for mutations affect different from inspiring English sources
At present, it is unclear why different mutations affect different tissues.
HOX-genes encode regulatory proteins with specific individual functions and mutations affect different aspects of the body plan [ 45].
Interestingly, the TFG mutations affect different domains of the protein: the coil coil domain in the HSP family, the P/Q rich domain in the family with neuropathy, suggesting different pathological mechanisms.
The three daf-2 mutations affect different parts of the receptor: e1370 disrupts the intracellular tyrosine kinase domain while m41 and m596 disrupt, respectively, the Cysteine Rich and Leucine Rich L2 extracellular domains [ 34, 39].
Considering that the gu mutation and the b g8 and i-3 mutations affect different types of chromatophores, the b g8-gu and i-3-gu double mutants should face more crucial optical problems than the b g8, i-3, or gu single mutants, and this appears to be detected as the additive effects of these mutations on the larval viability.
There is extraordinary variation in the frequency and spectrum of somatic mutations affecting different cancers, shedding light on the underlying mutational processes and disease etiology of these tumors (Wheeler and Whang, 2013).
A plasma protein called transthyretin often misfolds into amyloid because of at least 80 mutations affecting different parts of the body.
Therefore, mutations affecting different elements of the pathway lead to cell lysis [ 4, 5].
No definable clinico-radiological characteristics have been identified that separate microcephalies caused by mutations affecting different parts of the mitotic cycle.
The figures would possibly be slightly different if one considered the additive effect of multiples recessive deleterious mutations affecting different genes, each with lower allelic frequencies, and clearly different with different mutation rates.
Recent advancements in exome sequencing studies have demonstrated that the collection of de novo mutations affecting different genes in different individuals might explain a proportion of such common complex diseases as epileptic encephalopathies [ 24].
