Sentence examples for mutations activated the from inspiring English sources

It is also known that EGFR mutations activated the antiapoptotic protein Akt (Sordella et al, 2004), and that patients whose tumours have activated Akt are more sensitive to TKIs than patient whose tumours are phospho-AKT negative (Cappuzzo et al, 2004).

Leucine-rich repeat kinase 2 (LRRK2) is mutated in familial Parkinson's disease, and pathogenic mutations activate the kinase activity.

Mutations activating the N-RAS or B-RAF kinase components of the mitogen-activated protein kinase (MAPK) pathway are found in approximately 15% and 60% of human melanomas, respectively [ 3- 5].

Cheung, L.W. et al. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors.

D'Gama, A. M. et al. Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias.

The vast majority of TSHR mutations activate the Gαs/cAMP system, but only a few TSH receptor mutations can also activate the Gαq/11/IP pathway, although the effects of this pathway in the pathogenesis of ADNAH remain unknown [22], [23].

Confirmation that these novel mutations activate the PI3 kinase pathway awaits their functional characterisation.

PI3KCA mutations, present in 10 25% of CRCs [ 28, 39– 41], have been reported to be "gain of function" mutations activating the PI3 K/AKT pathway.

PIK3CA mutations activate the PI3 K-PTEN-AKT pathway, which is downstream from both the EGFR and the RAS-RAF-MAPK pathways.

These mutations activate the AGE-1 pathway and, in comparison to the wild type, they caused starved L1s to be more sensitive to H2O2.

These mutations activate the oncogenic properties of RAS proteins and it has been reported that they do so by inhibiting GTPase activity.