Sentence examples for mutations across studies from inspiring English sources

Inconsistency of results regarding the prognostic value of missense mutations across studies may be due to the fact that missense mutations may retain some activity, beyond the specific activity detectable in a particular study.

Thus, the recurrent nature of the DDR1R570Q mutation across studies suggests it may be a pathogenic event that provides a selective advantage in tumorigenesis, including endometrial tumorigenesis.

Differences in patient population (colorectal vs locally advanced rectal), treatments (chemotherapy vs chemoradiation) and sample sizes might account for the inconsistency of available data on prognostic role of KRAS mutation across these studies.

These significant interactions underscore the importance of studying mutations across genotypes and environments, and highlight the fact that results from a single background or environment may not necessarily hold true across other backgrounds and conditions.

Most site-directed mutagenesis studies that look at the DFE of all mutations across a range of mutational targets report Γ or unimodal similarly shaped distributions (Table 1).

Of note, the proportion of mutations in the four mutation subgroups was similar across study sites (P=0.2).

One student developed an algorithm to study adaptive mutations across the human genome.

There were 312 unique positions validated as somatic mutations across all patients in this study.

For instance, a 2007 study examined somatic mutations across the genome for colorectal carcinoma, one of the most common cancers occurring in epithelial tissue, and observed that a median of 76 non-silent mutations (15 considered to be in candidate cancer genes) had occurred in each tumor [ 2].

Across all studies that reported neuropsychiatric symptoms in patients carrying this mutation, apathy and disinhibition were again the most frequently observed (Table 1), but frequencies varied considerably across studies.

However, the findings are inconsistent across studies.