Sentence examples for mutations accompanied by from inspiring English sources

With longer disease duration, we found an additional, progressive accumulation of mitochondrial DNA deletions and point mutations accompanied by increasing numbers of complex I deficient neurons.

However, further investigations are needed to assess a possible clinical benefit of patients harboring the reported or other LMNA mutations accompanied by increased DNA damage.

DPC4 (Smad4), a tumor suppressor gene, exhibits frequent mutations accompanied by LOH in approximately 20%% of pancreatic cancers [ 19], but no mutations have been reported in gastric cancers [ 20].

Neurofibromatosis is due to germline mutations in neurofibromin 1, a RAS-GAP protein and negative regulator for RAS signaling, and germline NF1 mutations accompanied by somatic events have been identified in NF1 GIST cases [ 19].

In colorectal cancer, tumors with P53 accumulation in both the nucleus and cytoplasm tend to have a higher mutation rate and more multiple mutations, accompanied by the most unfavorable outcome [ 19].

In particular, nonsense mutations in exon regions are considered to be the most critical to phenotypic variations, and missense mutations accompanied by non-synonymous amino acid substitutions might influence protein functions.

These OMI mutants had either an inactive site, or the same active site mutation accompanied by a mutated PDZ domain (figure 2A).

The strain implicated in three cases of fatal sub-fulminant hepatitis harbored core promoter mutations, G1896A precore mutation (accompanied by the C1858T covariation), and several amino acid changes in the immune epitopes of the core protein.

The evaluation of etiology for SVT revealed JAK2V617F mutation accompanied by splenomegaly, thrombocytosis and bone marrow findings (megakaryocyte cellularity and clustering, presence of paratrabecular and dysplastic megakaryocytes without fibrosis) which indicates MPD, particularly essential thrombocytosis.

Although p53 mutation accompanied by complete loss of the wild-type allele is the most frequent event observed in many human cancers (Greenblatt et al, 1994), we found no preference of mutation with LOH (n=24), mutation without LOH (n=22) or LOH without mutation (n=21) in 94 Taiwanese OSCCs with germline heterozygosity in codon 72 (Arg/Pro).

Of the 50 stem 1 mutations we analyzed, 24 could not be linked with a reciprocal mutation; 12 of the remaining 26 mutations were accompanied by a reciprocal mutation exclusively within the same unit; and a further 10 could pair either within the same unit, or with another unit.