Sentence examples for mutations a year from inspiring English sources

The number increased steadily by two mutations a year, reaching 65 mutations for offspring of 40-year-old men.

The researchers reported that finding more than two mutations a year, or a doubling of mutations every 16 1/2 years, "is striking".

Tavtigian's company, Myriad Genetics Inc. in Salt Lake City, Utah, is hoping to develop a test for the HPC2 mutations within a year and a half.

The high-throughput deep sequencing studies we highlighted above have described an unprecedented number of novel mutations within less than a year.

Another family member with two copies of the mutation, a 34-year-old woman, had never menstruated.

The precise pRB LXCXE-dependent anti-growth mechanism that protects against Wap-p53R172H driven tumors is unclear since mutant p53 acts as a generator of mutations that drive tumorigenesis almost a year after the transgene has been silenced.

Vasen et al. showed that for carriers of MLH1 or MSH2 mutations, a surveillance interval of 1 2 years reduced CRC risk compared to 3-year intervals [ 28].

We also found a difference in μN between gymnosperms and angiosperms (0.18 × 10-9 and 0.92 × 10-9 mutations per year, respectively), representing a five-fold difference.

By sequencing the entire genomes of 78 parent-child trios, including five families comprising three generations, Kong et al. found that the number of mutations increases with the father's age (P = 3.6 × 10-19) with an estimated linear effect of 2.01 mutations per year (standard error = 0.17), and an estimated doubling of paternal mutations every 16.5 years using an exponential model [ 31].

For example, a halved generation time will double the estimate of Ne (given a fixed mutation rate per year), and a halved mutation rate per year will move the curve backward in time and also double the estimate of Ne.

We report the occurrence of a mild form of A-T, with biallelic ATM mutations in a 44-year-old breast cancer patient (A-T213) who was investigated following a severe early and late reaction to radiotherapy.