Sentence examples for mutations a somatic from inspiring English sources

At some time during the acquisition of these initial D mutations, a somatic mutator mutation may occur.

Consequently, it was not possible to determine whether this deleterious mutation was a germline mutation or a somatic mutation.

Further, in 30 – 85% of the sporadic ovarian carcinomas both a TP53 mutations and a somatic BRCA1/BRCA2 mutation have been found [ 18, 20, 25].

Finally, in the two paths imagined by the authors, why does an epigenetic mutation precede a somatic mutation?

Similar frequencies of mutations are observed in patient genomic DNA, indicating that mutations have a somatic origin.

The prevailing paradigm in cancer research is the somatic mutation theory that posits that cancer begins with a single mutation in a somatic cell followed by successive mutations.

The prevailing paradigm in cancer research is the somatic mutation theory (SMT) that posits that cancer begins with a single mutation in a somatic cell followed by successive mutations [ 1].

Using our somatic mutation formula, a somatic structural event is once again indicated by such evidence appearing primarily and confidently in the tumor.

Patients harboring a germline mutation would require a somatic mutation in the wild-type allele to initiate lesion formation.

It is not clear that somatic mutations will have a uniform effect on gene expression for the mutated gene, although a somatic mutation in a causative gene may result in a unique gene expression signature.

These data document that the AR gene mutation in E006AA was a somatic mutation that likely occurred prior to gene amplification and X-chromosome duplication.