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Moreover, the study revealed that the B. subtilis genome is quite flexible with respect to adaptive mutations, a property, which is very important for strain engineering.
The evidence that the C4F6 antibody recognizes a conformational epitope derives from its high reactivity to fALS mutant SOD1 encoding other disease-associated mutations; a property that we observe in fixed, but otherwise untreated, transfected cultured cells [ 27].
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These conservative mutations may be indicative of a selective pressure to maintain these mutations, together with a property encoded by a gene present in close proximity to glmM, a property that has yet to be identified.
For example, the anomalous response of FNfn10 to mutation is not solely a property of the core as we had previously suggested.
Practically, a mutation operator randomly selects a property amongst those that are non-optimal in the current template (d i – t i ≠ 0).
Proteins that functionally interact within a cell often demonstrate a property termed synthetic lethality; mutations in either gene may individually support viability, but when combined caused lethality [ 117].
Overall, this suggests that a selected number of mutational escape mutations increase binding properties of the respective peptide/MHC class I complexes to ILT4, while other variants do not.
The mutations confer a cytotoxic property on the enzyme that is poorly understood [ 16].
In addition to permissive NA mutations, other properties, such as antigenic novelty, which might provide an advantage to oseltamivir-resistant viruses and facilitate their spread, should also be monitored.
Because of its mutation-inducing property, EMS is also very useful for producing leaky alleles in forward genetics.
Another explanation could be the possible emergence, with time, of cell mutations conferring properties of resistance to the drug.
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