Sentence examples for mutations a process from inspiring English sources

If these cells and their daughter cells are not detected by the immune system, they may continue to replicate and accrue further deleterious mutations, a process that may, given time, lead to cancer [1].

Alternatively, polymorphism within a mitochondrial genome may be depressed through selection against linked deleterious mutations, a process known as "background selection" [ 12- 14].

Besides its position along the chromosome, our data indicated that DNA methylation observed in the promoter region of homoeologous group 5 and 7 may have contributed to their transcriptional repression and may have favored an increased evolution rate at TaMET-5A1 and 5D1 leading to the accumulation of deleterious mutations, a process known as pseudogenization [ 45, 46].

Exposing the genome to the spread of selfish elements is one of the costs of biparental inheritance; however, we also provide evidence of one beneficial effect of recombination: slowing the accumulation of slightly deleterious mutations, a process known as Müller's ratchet (Muller 1964).

Often, one member of a duplicated pair becomes silenced through degenerative mutations, a process known as nonfunctionalization. Though most fixed genes nonfunctionalize, some undergo neofunctionalization whereby one of the duplicates acquires a beneficial mutation which leads to a gain of function.

An interesting feature of the genome is that 150 of its genes have been rendered inactive by natural mutation, a process that affects any gene that the organism no longer needs.

Finally, no understanding of influenza seasonality is complete without consideration of the intrinsic aspects of the disease and the ability of the virus to continually reinfect humans by escaping recognition by host antibodies via frequent mutation, a process of selectively driven evolution termed "antigenic drift" (Webster et al. 1982).

Hoping to patch up the protein, researchers at Johns Hopkins University in Baltimore, Maryland, and Memorial Sloan-Kettering Cancer Center in New York City, took mutated p53 genes and introduced additional random mutations by a process called PCR mutagenesis.

These, too, showed more tropical than temperate mutations.By a process of elimination, therefore, the three researchers were left with the conclusion that, by pushing metabolic rates up, tropical heat causes more mutation and thus more speciation.

Fibroblast growth factor-1, a member of the 3-fold symmetric β-trefoil fold, was subjected to a series of symmetric constraint mutations in a process termed "top-down symmetric deconstruction".

This increases the damage done by recessive deleterious mutations, in a process known as inbreeding depression.