Sentence examples for mutations a considerable from inspiring English sources

Even without mutations, a considerable fraction of the reads were not mapped and more than 10% of the genes differed more than 50% for the true expression level.

Second, the sequencing process itself could introduce phantom mutations in a considerable number of mtDNAs [23], [28], [29].

However, cells progressing through anaphase with delayed Cdc14 activation due to FEAR mutations incur a considerable loss in viability, probably due to chromosome segregation defects [ 8].

The conversion rate for endogenous protein turnover (kdegENDO) was kept fairly constant (0.0025 ± 10%) for all variants assuming that none of the mutations has a considerable impact on protein folding.

Although mutations of 3 m1 and 2 m3 together had a much greater effect than 3 mutationion alone, the 3 mutationion alone had a considerable effect on the trafficking behavior and activity of long PINs.

CNA of the KRAS locus occur independently of the KRAS mutation status in a considerable percentage of colorectal tumours (21.2%) as assessed in a large and unselected mCRC population.

However, our present findings indicate that papillary carcinoma with BRAF mutation, which comprises a considerable percentage of differentiated thyroid carcinomas, might not be the major origin of anaplastic carcinoma.

The clinical presentation, the age of onset and the progression rate of NBIA are highly variable, even amongst siblings with identical underlying mutations, and there is a considerable degree of phenotypic heterogeneity even in cases with PANK2 mutation-positive status (Thomas et al., 2004).

These statistics indicate that mutations affecting splicing comprise a considerable proportion of genetic disease etiology.

Meanwhile, a large spectrum of mutations was found in a considerable number of genes expressed in early cardiogenesis.

N- and K-Ras mutations are found in a considerable percentage in newly diagnosed patients (about 40%).