Sentence examples for mutations a collection from inspiring English sources

25 In order to directly measure the fitness effects of mutations, a collection of mutants must first be created.

Because general metabolic and gene expression functions might also affect both of these processes, we applied a high-throughput whole genome sequencing strategy to identify the causal mutations in a collection of TS Eos/ Ste mutants that all share these two defects.

We sought to determine whether one-step WGS/SNP mapping could be used to systematically map suppressor mutations using a collection of 20 suppressors isolated against a temperature-sensitive allele in the kinase MBK-2.

Because many of the HAs in our libraries contain several mutations, these preferences do not simply correspond to the fitness effect of each individual mutation to the WSN HA rather, they represent the average effect of each mutation in a collection of closely related HA mutants.

A recent study demonstrated the distribution of point mutations conferring resistance in a collection of MDR M. tuberculosis isolates from Panama using a multiplex PCR platform [ 27].

OncoMap is a high-throughput mass-spectrometric based cancer gene mutation profiling platform incorporating a collection of OncoMap 3 core -460 assays interrogating known mutations in 33 cancer genes [ 21, 22].

This hypothesis, or any hypothesis about a collection of mutations, admits the possibility of including mutations with a wide range of penetrance.

We have used this approach to successfully map a collection of mutations from an ethyl methanesulfonate−based mutagenesis screen on the third chromosome.

We demonstrate the usefulness of using pairs of dominant markers through the mapping of a collection of mutations identified in an EMS-based mutagenesis screen.

To determine whether this method could be used to facilitate mapping after large-scale forward genetic screens, we used pairs of dominant markers to simultaneously map a collection of mutations identified in an EMS-mutagenesis screen on the third chromosome.

A collection of mutations and their disease significance and influence on the function of the protein together with common variations within the human population would facilitate our understanding of the variations and disease association.