Sentence examples for mutational variation in from inspiring English sources

Furthermore, extensive mtDNA mutational variation in humans has the potential to render some individuals or lineages more susceptible to mitochondrial disease and earlier onset of degenerative aging-related phenotypes than others.

Biologically this insensitivity means that the expression levels of genes corresponding to singular components will be kept virtually constant despite stochastic or mutational variation in the expression process rates.

To place the mutational variation in context, we compared the inherited (among-line) variance in the MA experiment to that observed among a set of inbred lines established to capture the standing genetic variation in a natural population.

To investigate mtDNA mutational variation in Caenorhabditis, we sequenced nearly complete mitochondrial genomes from a set of 250-generation C. briggsae MA lines: 21 MA lines derived from natural isolate HK104 (Okayama, Japan) and 18 MA lines derived from natural isolate PB800 (Dayton, OH).

1 Coxiella burnetii displays antigenic (phase) variation associated with loss of virulence and mutational variation in the lipopolysaccharide. 1 High levels of antibodies to phase I antigens are detected during chronic Q fever, whereas antibodies to phase II antigens are produced in acute disease.

Phenotypic selection benefits from mutational variation (reviewed in [ 22]), but it is not clear how GS might, considering that new mutant effects will not immediately be present in the training population.

Rifkin et al have shown that in as little as 200 generations, mutational variation can appear in up to 39% of the genome, a factor we expect to contribute to the transcriptional variation we observe [ 29].

Although these combined studies have provided an important step in understanding between-species mtDNA mutational variation, the model organisms used in these studies are all very distantly related from one another.

Subsequently, we analysed mutational variation using SNP and DIP detection algorithms in the CLC Genomics Workbench (Additional files 5, 6).

In allopolyploids, mutational variation may arise between homologous sequences within individual subgenomes and between homoeologous sequences among subgenomes, in addition to paralogous variation between duplicated gene copies [ 51].

We employed a more rigorous test to distinguish between mutational variation and fixation biases for the shift in background substitutional patterns in D. saltans/willistoni.