Sentence examples for mutational variants of from inspiring English sources

The advantage here may be related to a greater ability to recognize mutational variants of an epitope.

Analysis of the conservation and mutational variants of these H1N1 HLA-restricted epitopes was revealing of the marked effect that single aa mutations may have on the representation of T cell epitopes in evolving virus populations.

Multiple mutational variants of Cby have been created in an attempt to circumvent the signal-broadening problem due to conformational exchange and self-association occurring in the C-terminal region of the protein.

From a systematic analysis of more than 50 mutational variants of AcP, Chiti et al. rationalised the propensities of some sequences to aggregate more rapidly than others, based simply on the physicochemical characteristics of the polypeptide chain: hydrophobicity, secondary structure propensity and charge [185].

Continuing interest in FKBP12 as a target for clinical therapies is indicated by the deposition of over 30 X-ray structures of the wild-type and mutational variants of the human protein both free and bound to either small-molecule inhibitors or in physiological protein protein complexes.

This method has proved to be of great relevance in studies of Alzheimer's disease in which the amyloid β-peptide (Aβ) has been expressed (30– 32), for polyglutamine-repeat disorders, such as Huntington's disease (33– 35), and for a familial amyloidotic polyneuropathy associated with mutational variants of transthyretin (36, 37).

For instance, eGFP is a widely used mutational variant of wild-type GFP owing to its superior brightness, photostability and relatively small sensitivity to pH (Cormack et al., 1996).

Such resistance is encoded by an increasing number of different point-mutational variants of classical broad-spectrum β-lactamases (BSBL).

Both methods allow similarly large numbers of mutational variants to be simultaneously compared and competed, and both methods can potentially be adapted to a range of molecular biology enzymes that act on their own templates, such as restriction endonucleases or DNA ligases.

Population genetics has historically focused on mutational variants comprised of single nucleotide change.

Mutational variation emerging within an Attamyces monoculture could provide genetic diversity for symbiont choice (gardening biases of the ants favoring specific mutational variants), an analog of artificial selection.