Exact(3)
H5N1 protein entropy patterns of the 1997 to 2006 isolates from humans (1,055 sequences) and birds (4,361) were grossly similar and reflect the high mutational variability in amino acid composition of proteins of even a single subtype influenza A virus (Figure 3).
Discovering these host factors may not only unravel fundamental principals of viral modes of operation, like their replication, but also, notably, may lead to promising drug therapies which are not affected by the high mutational variability in viral populations.
Views on the importance of mtDNA mutational variability in tumours vary from complete disbelief [ 61] through cautious acceptance of at least some data [ 62] to optimistic belief that mitochondrial studies in cancer patients might be employed to search for reliable disease markers [ 6].
Similar(57)
These findings demonstrate that inherited (not mutational) variability is important in the angiogenic phenotype and affects outcome.
Both levels thus play a key role in the mutational variability of the phenotype, and hence in the long-term evolutionary success of the lineage.
Incorporating into the various regions of genome, they play a significant role in increasing mutational variability and reorganization of the genome.
Further, mutational variability analysis pointed that most of the amino acids were well conserved.
The delayed neutralizing antibody response against the noncytopathic lymphocytic choriomeningitis virus (LCMV) in mice correlates with low precursor frequencies of B cells specific for the neutralizing antigenic site [8], with mutational variability of the relevant glycoprotein determinant [9] and with CD8+ T cell-mediated immunopathology [10].
In their definition, they focus on the generation of the genetic substrate available for selection through mutational variability and recombination.
In their definition, they focus on the generation of genetic substrate available for selection through mutational variability and recombination.
No relation between mutational variability of this mtDNA region and response to chemotherapy was proven.
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