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In their definition, they focus on the generation of the genetic substrate available for selection through mutational variability and recombination.
In their definition, they focus on the generation of genetic substrate available for selection through mutational variability and recombination.
Incorporating into the various regions of genome, they play a significant role in increasing mutational variability and reorganization of the genome.
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Both levels thus play a key role in the mutational variability of the phenotype, and hence in the long-term evolutionary success of the lineage.
No relation between mutational variability of this mtDNA region and response to chemotherapy was proven.
Although informative, reporter constructs do not reveal the full spectrum of possible mutations, nor do they capture mutational variability associated with genomic architecture, sequence contexts, or processes such as replication and transcription.
H5N1 protein entropy patterns of the 1997 to 2006 isolates from humans (1,055 sequences) and birds (4,361) were grossly similar and reflect the high mutational variability in amino acid composition of proteins of even a single subtype influenza A virus (Figure 3).
These findings demonstrate that inherited (not mutational) variability is important in the angiogenic phenotype and affects outcome.
The delayed neutralizing antibody response against the noncytopathic lymphocytic choriomeningitis virus (LCMV) in mice correlates with low precursor frequencies of B cells specific for the neutralizing antigenic site [8], with mutational variability of the relevant glycoprotein determinant [9] and with CD8+ T cell-mediated immunopathology [10].
Unlike cases LGSC-9 and LGSC-12, sequencing of 4 primary and 4 recurrent samples revealed extensive mutational variability.
Further, mutational variability analysis pointed that most of the amino acids were well conserved.
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