Sentence examples for mutational target in from inspiring English sources

Therefore, the polypyrimidine tract, in which we found mutations, may be a mutational target in MSI-positive tumours, and mutations therein may be involved in carcinogenesis and the progression of MSI-positive tumours.

We propose that the occurrence of one highly deleterious mutational event (i.e. the ψND5-2 insertion and associated ND5 deletion events) presents a novel mutational target in the mitochondrial genome where most all new mutations are expected to reduce homology between ψND5-2 aND5ND5, thus reducing the likelihood of deleterious mitochondrial genome deletions.

Although the MAP-kinase cascade is a mutational target in several tumor entities, activation of this pathway by mutations in either GNAQ or GNA11 is specific for uveal melanomas and other nonepidermic melanocytic lesions like blue nevi 19, 20, 21.

An early mutational target in cells with defect DNA mismatch repair may be the RAS/RAF pathway.

The KN63 cell line contains copies of a shuttle vector with the Escherichia coli gpt gene as a mutational target in its chromosome.

Tumor Susceptibility Gene-101 (TSG101) promotes the endocytic degradation of transmembrane proteins and is implicated as a mutational target in cancer, yet the effect of TSG101 loss on cell proliferation in vertebrates is uncertain.

Genetic analysis over the past 30 years has defined the major mutational targets in the human genome that are associated with the formation of glioma [ 4].

It is also interesting to note that several recent studies have shown this pathway to be one of the major mutational targets in pancreatic and other cancers [ 89– 91].

This asymmetry is first justified with the potentially lower number of developmental and behavioural mutational targets in outcrossing traits than selfing traits, as C. elegans hermaphrodites are only slightly modified females with a few sperm cells.

Third, the duplication may represent a precursor enhancing the likelihood of the substitution of a beneficial mutation through an increase in the mutational target and in local mutation rates.

Very often, 5-methylcytosines (mC), when part of a dipyrimidine sequence, are seen as preferential sites of CPD formation and also as preferential mutational target sites in mammalian cells.