Sentence examples for mutational subtype for from inspiring English sources

The implications of mutational subtype for both prognostic and predictive value are being increasingly understood.

Figure 2C graphs the average IC50 for all the possible KRAS mutational subtype and KRAS copy-number combinations.

We report a strong correlation between both specific KRAS mutational subtype and CNV, and sensitivity to MEK inhibition.

Given the potency of MEK162, it may be a promising new therapy for patients with pancreatic cancer and KRAS mutational subtypes, and CNV may serve as important biomarkers for selecting patients that benefit from MEK-targeting based on these preclinical data.

> -wrap-foot> OPA1 mutations exert a deleterious effect on in vivo mitochondrial function, irrespective of mutational subtypes and disease severity.

PDAC can be classified based on mutational subtypes and 18gene alterations.

Potential explanations for the discrepant findings across investigations include inability to identify specific p53 mutational subtypes when using immunohistochemistry as a proxy, differences in metabolic activation and detoxification of PAHs between study populations, and chance findings.

The resulting data demonstrate MEK162 sensitivity was associated with KRAS mutational subtypes and CNVs in the pancreatic cancer cell lines.

However, our report is the first to suggest that specific KRAS mutational subtypes can also be used to predict response to targeted therapy.

Variance describes subtyping for classes with type parameters.

However, for rare cancer subtypes for which large patient cohorts are difficult to recruit, additional validation steps may be needed to prevent false positives contaminating the data and obfuscating the associations between mutational profiles and clinical outcomes.