Sentence examples for mutational studies that from inspiring English sources

This conjecture is supported by both the crystal structure of the Chk1 catalytic domain and mutational studies that reveal C-terminal disruptions of Chk1 exhibit increased intrinsic kinase activity even in the absence of damage [21].

Mutational studies that replaced the native N-terminal residue of LF with known N-end rule stabilizing or destabilizing residues confirmed that the N-terminal residue plays a significant role in determining the potency of LT for cultured cells and experimental animals.

The mutational studies that are summarised in Table 1 do reveal some conflicting results, however, and as previously mentioned these are likely due to a number of factors including geographical variation/influence, sample source preservation and methods used for DNA isolation.

In addition, the close interconnection of both trajectories is also mirrored by mutational studies that identified two conserved amino acids in the I-helix region of AOS.

Here, we present different mutational studies that suggest that within the Rio2 Slx9 RanGTP complex, Slx9 optimally orients the NES and improves its affinity for Crm1.

4a Although Ub can be enzymatically phosphorylated in preparative quantities with recombinant PINK1, 10 this approach is restricted to Ser65 and is not compatible with mutational studies that seek to target sites in ubiquitin that might be required for kinase recognition.

The first linkage and mutational studies suggested that mutations in these two genes would account for the majority of high-risk breast cancer families, but recent studies show how the proportion of families due to BRCA1 or BRCA2 mutations strongly depends on the population and the types of family analyzed.

Mutational studies showed that groESL operons within the same genome are induced by different stimuli and that these genes are involved not only in stress tolerance, but also in the nodulation and nitrogen fixation processes.

Comparative structural and mutational studies demonstrated that residues outside the major substrate-binding site of bsYpgQ are responsible for the species-specific substrate preference.

Mutational studies uncovered that the phenyl group of Tyr99 in the substrate recognition peptide and Tyr124 in Loop 1 are essential for catalysis, consistent with the structural information that the benzene groups of Tyr124 and Tyr99 likely made π-π stacking interaction with the uracil ring of the substrate.

Mutational studies indicated that two α-helices aa30-599 and aa466-495) of the TTE-HsdM subunit are important inter-subunit interaction sites in the TTE-M2S1 complex.