Sentence examples for mutational strategy in from inspiring English sources

We attempted to rationalize the site-directed mutational strategy in order to predict functionally critical residues of CaMdr1p.

Using the same mutational strategy, mutations were introduced into the ERev protein and the effect of mutations was evaluated in a Rev nuclear export activity assay (Fig 4A).

A mutational strategy that combines elimination of buried free cysteines and secondary mutations that enhance thermostability to achieve a substantial gain in functional half-life is described.

Our mutational strategy was based on the solved tertiary structure of the Homo sapiens endophilin-A1 BAR domain [hEndoA1 BAR; [8]].

On the other hand, comparative studies and efforts in directed evolution have revealed that there are many mutational strategies that lead to high stability, some of which are not easy to define and rationalize.

In this paper, we apply in silico approaches with the goal of associating particular aspects of FlbB functionality with specific motifs and residues in order to inform the design of site-directed flbB mutational strategies.

Various mutational strategies have been used to modify and optimize GFP.

The transcriptional, mutational-independent strategy used in the present study is aimed at overcoming the heterogeneity of mutations in the RHO gene.

Whalen, S. et al. Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum.

We designed a mutational screening strategy based on cDNA from monocytes to find out whether the mutational analysis could be performed in mRNA from a source less invasive than the muscle biopsy.

Considering that autosomal dominant retinitis pigmentosa (adRP) is the most genetically heterogeneous inherited disease in humans, we designed this mutational-independent strategy to overcome the technical and economical magnitude of allele-specific targeted-designed therapeutics.