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We can apply a similar theory the BRAF mutational status for the PTC foci, because BRAF mutations have been identified in about half of the PTCs examined 23.
All patients had the mutational status for JAK2 V617F determined using the allele specific-PCR assay on DNA purified from granulocytes, as reported [19].
The mutational status for KRAS exon 2, BRAF exon 15, and PIK3CA exons 9 and 20 was determined in all 112 consecutive patients with mCRC whereas.
The mutational status for the TSHR, GNAS and NRAS genes was determined for all the FTA and FTAb explored in studies by microarray (26 FTA and 17 FTAb) and RT-PCR (8 FTA and 8 FTAb).
According to their specific gene-expression profiles as well as their mutational status for RAS and PAX8-PPARγ genes [7], oncocytic tumors should be considered as distinct from the other follicular tumors.
To further evaluate this finding we analyzed 120 additional patients with unresectable metastatic colorectal cancer who previously had their primary tumors evaluated for KRAS mutational status for clinical purposes.
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Likewise when mutational status of k-ras for the tumour was compared for R0, the non-significant role was maintained (p = 0.09).
Even with clear functional interaction between NOTCH1 and PTEN genes, no association for mutational status of these genes was found.
In addition, 9 samples from transbronchial biopsies were also analyzed for mutational status of the EGFR Tyrosine kinase domain.
All familial patients were analyzed for the mutational status of BRCA1/2 genes as reported previously.
BRAF mutational status data for 15 patients who were evaluable for response are shown in Figure 1.
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