Furthermore, a statistically significant association was not observed between aberrant methylation of DBC1 and other important known prognostic factors in AML harboring a normal karyotype, such as NPM1 mutations, FLT3 mutational status, and response to treatment.
PCR products featuring an aberrant melting curve were further processed to confirm the patient mutational status and to identify the mutation type.
None of these mutations were Notch or angiogenesis pathway related and there was no correlation between mutational status and time to treatment failure.
Early association studies between mutational status and response to Aza indicate a higher response rate for TET2-mutated patients and a lower response rate for ASXL1-mutated patients.
Clinicians will order tests that evaluate pathway activity as well as mutational status and will apply these results in real-time in the clinic.
To evaluate PIK3CA mutational status and c-erbB2 gene amplification in a series of primary uterine serous carcinomas (USC) cell lines.
Finally, the ic50 values for l-alanosine of the 60 cell lines were correlated to the p53 mutational status and expression of p53 downstream genes.
We examined RAS mutational status and correlated this with presenting morphology, cytogenetics, clinical outcome and other gene aberrations in a large cohort of Chinese acute myeloid leukemia (AML) patients.
No correlation was seen between BRAFV600E mutational status and clinical activity.
These findings suggest that the TP53 mutational status and altered TP53 activity might influence the sensitivity of cells to SAG.
We downloaded the free database of mutational status and zygosity status for each gene (on April 8th 2009).
