Sentence examples for mutational spectrum for from inspiring English sources

To explore the mutational spectrum for diverse mutator alleles in a whole-genome context we devised a mutation accumulation experiment.

Mismatch repair defective cells have historically been associated with microsatellite instability, but the distinctive mutational spectrum for single base substitutions was not well established.

Having a homogeneous mutational spectrum for the XPC gene has greatly simplified the molecular diagnosis of XP-C in the region [ 6, 8, 13].

The power to discover novel, disease-causing or protective alleles potentially becomes even larger when combining data from different studies, thereby increasing the number of controls and cases for related phenotypes, and helping adjust for the mutational spectrum for individuals of diverse ethnic backgrounds.

Mutational spectra for both viral genotypes were dominated by point mutations as not a single insertion or deletion was observed (table 2).

Furthermore, it is hoped that whole-genome mutational spectra for cancers of unknown etiology - for example, breast or pancreatic cancer - will bring forward new hypotheses regarding potential agents that have compatible mutational specificity and should further be investigated as causative agents of human cancer.

We believe that the development of HGMD Professional together with the suite of Advanced Search tools provides the user with a unique resource that can be used not only to acquire evidence to support the pathological authenticity and/or novelty of detected lesions, but also to obtain an overview of the mutational spectra for specific genes.

The CAN1 marker used as a primary screen for mutator alleles has been sequenced extensively to describe the mutational spectrum of mutator alleles (Huang et al. 2003).

a Class I: combined mutational spectrum of the tumor types for which H0 is rejected in comparison of synonymous vs. non-synonymous substitutions:brain, liver, lung, colon, mouth, larynx, ovary and skin.

b Class II: combined mutational spectrum of the tumor types for which the test did not find enough evidence, probably, because of the small sample size: bladder, breast, prostate, esophagus, colorectal, hematopoietic, stomach, and pancreas.

The mutational spectrum of these mutations has recently been described (Lee et al. 2012).