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Candidate cancer genes instead derive from large-scale mutational screenings of cancer samples and have been identified using statistical methods with poor or no experimental follow-up.
Mutational screenings of ASDII disease genes are suitable to systematically assess the frequency of mutations within one single gene in a predefined patient cohort.
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The possibility of obtaining nucleotide sequences in the range of hundreds of millions base pairs from various types of DNA templates allows for example to extend mutational screenings to very large portions of the genome, an experimental strategy that would be too expensive and time consuming to perform with methods based on the Sanger procedure [1].
Several mutational screenings have been reported, many of them based on isolated cases/families and the identification of private mutations.
However, mutational screenings in linkage assay-identified regions using the classical candidate-gene approach did not identify any clear pathogenic variants [4], [5], [6].
Screenings of the film "Amandla!
The festival features several screenings of regional films.
Independent Film Festival begins with screenings of documentaries.
Paramount's now cancelled all screenings of Team America?
He remembers watching outdoor screenings of "Rambo" with his dad.
"Sony has authorized screenings of THE INTERVIEW on Christmas Day.
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CEO of Professional Science Editing for Scientists @ prosciediting.com