Sentence examples for mutational robustness and from inspiring English sources

How the thermodynamic stability effects of protein mutations (ΔΔG) are distributed is a fundamental property related to the architecture, tolerance to mutations (mutational robustness), and evolutionary history of proteins.

Viruses and perhaps bacteria might thus benefit from large population sizes and high mutation rates that drive an increase in the mutational robustness and stability of their proteins, which in turn enhances the capacity of these proteins to rapidly change their sequences and evolve new functions.

Note that the extent of polymorphism depends on the product of the mutation rate and population size, meaning that proteins from populations of different sizes are predicted to evolve to different levels of mutational robustness and stability even if they experience the same mutation rate.

Adaptation moves the protein to a region in the fitness landscape characterized by decreased mutational robustness and increased ruggedness, as measured by fitness effects of mutations and epistatic interactions for TEM-1's original function.

This trade-off between the mutational robustness and developmental speed may provide an evolutionary transition from short to long germ mode.

Furthermore, network architectures composed of FFLs and/or negative FBLs exhibit a trade-off constraint between mutational robustness and developmental speed, which may play a crucial role in the evolution of segmented body plans.

Recent work focusing on microRNA precursors (pre-miRNAs) has reported that pre-miRNAs show a significant enrichment of mutational robustness (Borenstein and Ruppin 2006; Shu et al. 2007; Szöllősi and Derényi 2009).

when, instead of the intrinsic replicative ability, Ai, the product of the replicative ability and mutational robustness (the effective fitness) are compared, and the transition to error catastrophe arises naturally as a result of natural selection acting on the difference of fitness.

Hence, our results are in tune with the suggestion that antagonistic epistasis would promote evolvability [ 30], and that evolvability and mutational robustness are inversely correlated, at least in the short term [ 31].

There was a negative relationship between environmental and mutational robustness such that disruption strains that were more robust to environmental stress tended to be less robust to mutational stress.

In addition, the energetic features of the molecule manage its structural robustness to both mutational and environmental perturbations [ 22, 27], and this explains the strong correlation between environmental and mutational robustness.