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The final outcomes were an overall mutational rate of 3.95 × 10−8 substitutions per nucleotide per year (1 mutation every 1522 years) on the entire molecule and 1.57 × 10−8 substitutions per nucleotide per year (or 1 mutation every 4120 years) on the coding region alone.
The high mutational rate of the virus and frequency of interspecies transmission leading to novel virus subtypes will reduce the current vaccine efficacy and make influenza infection highly unpredictable [6, 7].
The error rate of different DNA polymerases has effects on the mutational rate of amplified large DNA fragments.
The mutational rate of CpGs.
The only exception was seen in the mutational rate of mucinous tumors.
All 12 males were fertile and produced a ms(3 k81 mutational rate of 25% in the germline (Table 1).
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The method proved robust, with minimal variability in predicted mutations and mutational rates of human DNA when different random selected samples were analyzed (Additional file 6: Table S3) or on comparison of mammalian genomic DNA and RNA datasets where selection pressures are expected to be similar between species (Table 1; Figure 5).
How these mutations occur in real time and mutational rates of these human coding sequences have not previously been studied.
The investigation of mutational rates of CNVs is critical to understanding genomic instability and the etiology of the copy number variation (CNV -related traits.
Based on the position and mutational rates of Unknown 1, our study corroborates the divergent nature of Unknown 1.
Mutational rates of single and combined drugs at antimicrobial concentrations equal to the resistance breakpoints were also calculated.
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