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The high mutational rate and reinduction of Rag genes suggest an antigen-driven process.
The heterozygosity observed at some of the loci could also be due to high mutational rate and mutational bias at SSR loci [ 35].
Additionally, the high copy number per cell, low recombination rate, high mutational rate, and dominantly maternal heritance have made the mitochondrial genome a powerful tool for evolutionary studies.
Based on this, two separate calculations were done – one using a 3.6% per million years mutational rate and one based on a 11% per million years mutational rate.
Our approach showed that, if the averaged mutational rate is known, a number of other biological parameters, such as the initial mutational rate and the mutational function, can be determined by using our proposed model.
20 Two regions of mtDNA were amplified and subsequently sequenced: 1 in the noncoding hypervariable region MT-HV2, known to have a high mutational rate, and 1 in the highly conserved, peptide-coding MT-CO3 gene.
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For example, microsatellites are abundant in genomes and possess mutational rates and processes that are notably different from point mutation (Ellegren 2004).
In men, it is thought that the spermatogonial stem cell divisions occurring over the life-course of males result in higher mutational rates and cytogenetic abnormalities in the sperm of older men [10], [11].
In conclusion, the probability of mitonuclear coadaptation depends on standing variation, modulated by mutational rates, and intensity of purifying selection.
Measurements required to parameterize such models are reduced to mutational rates and effects in one baseline environment and the decay rate of the wild type in each environment.
The knowledge of VNTR mutational rates and the factors affecting them would make MLVA more effective for epidemiological or microbial forensic investigations.
More suggestions(15)
mutational pressure and
mutational approach and
mutational signature and
mutational heterogeneity and
mutational evolvability and
mutational spectra and
mutational diversification and
mutational saturation and
mutational fodder and
mutational status and
mutational analysis and
mutational variance and
mutational tolerance and
mutational event and
mutational load and
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