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The different mutational properties of these two classes of markers result in differences in heterozygosities and allele frequencies that may have implications for their use in assessing relatedness and evaluation of genetic diversity.
If, for whatever reason, the mutational properties of a reference genotype (or species) are atypical of the mutational properties of the taxon as a whole, conclusions from that study will be misleading.
The differences between SNPs and SSRs in levels of genetic diversity result from mutational properties of these two marker types.
Our findings provide a framework for understanding the regional mutational properties of eukaryotes, revealing a sharp difference between fungi and multicellular species.
Here we describe a new approach to help distinguish between hot-spots and melting-pots for a species that is based on the mutational properties of DNA sequences.
Thus, it is of considerable importance to establish the generality of the results by investigating the mutational properties of multiple genotypes within multiple related species.
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Here, we examine the influence of experimental design and mutational properties on the mapping success of BSA-seq when the density of segregating sites is low, with the goal of providing a general framework for large-scale mapping of small effect mutations after a mutagenesis screen.
Since each protein has a different size (coding sequence length) and different number of mutations, we normalized mutation occurrence (number of mutations in a gene) by coding sequence length for the fair comparison of the mutational property of proteins.
To determine how power for detecting different types of mutations varies with mutational properties and experimental parameters, we developed a flexible simulation that models mapping via BSA-seq computationally.
Characterization of regional biases in a broader range of species would improve our understanding of genomic mutational properties.
First, as equation (4) suggests, the fitness equilibrium is independent of the mutational properties.
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