Sentence examples for mutational profiles of from inspiring English sources
The distinct mutational profiles of GNAS and KRAS mutations might be potentially helpful in determining the origins of metastatic mucinous tumours in clinical situations.
In a series of 96 thyroid tumours whose mutational profiles of BRAF, IDH1 and NRAS mutations and RET/PTC were previously determined, we investigated MLH1 and MGMT expression and methylation status by qPCR and methylation-specific PCR after bisulphite treatment, respectively.
Recently, efforts to establish mutational profiles of lung cancer have been undertaken and showed promising results for mutation-specific treatment, for example of tumour cells showing ras mutations, with an Hsp90 inhibitor [ 43].
Thus, mutational profiles of tumors can help prioritize anticancer therapy.
Mutational profiles of 153 Korean myelodysplastic syndrome (MDS) patients were investigated.
Detailed patient characteristics as well as mutational profiles of tumor tissues and cell lines are presented in Table 2. Representative data from SSCP analysis and DNA sequencing are shown in Figure 2. Screening of exons 11 and 15 of the B-RAF gene resulted in the detection of mutations in 53/97 (54.6%) tissue biopsies and 53/105 (50.5%) biopsy-derived cell lines (Tables 2 and 3).
The unique mutational profile of GATA3, dominated by frameshift mutations, may prompt further investigations about their mechanism of onset and significance.
According to the Sanger Institute catalogue of somatic mutations in cancer (*COSMIC database, Catalogue of Somatic Mutations In Cancer, http://www.sanger.ac.uk/), the mutational profile of the above cited cell lines is reported: Detroit562 cells harbour a H1047R mutation in the PI3K gene; Kyse30 cells harbour a Q61L mutation in the H-Ras gene.
We investigated the nuclear mutational profile of oncocytic tumors to pinpoint the mutations that may trigger the early oncogenic hit.
The mutational profile of IDH1 and IDH2 is peculiar as the mutations affect only single evolutionarily conserved residues (arginines R132 and R172, respectively).
We evaluated the mutational profile of 'hot spot' regions of three oncogenes frequently mutated in solid cancers: KRAS (exon 2), EGFR (exons 18-19-20-21) and PIK3CA (exons 9 20), as described in the Additional file 1.
