Sentence examples for mutational process for from inspiring English sources

10.7554/eLife.02935.017 Figure 5. Selection and mutational process for mtDNA somatic substitutions.

In the model, we tracked the VNTR and SNP bacterial genotype of each infected host, with a defined mutational process for each genetic marker.

Including the immediate sequence context allows better differentiation between different mutational processes; for example, distinguishing between C > T mutations due to the formation UV-light induced photodimers (i.e. C > T mutations at dipyrimidine sites such as Tp CpC or Cp CpC) from C > T mutations due to deamination of 5-methylcytosine (i.e. C > T mutations at CpG sites).

The mutational processes for MHC and microsatellites are different and therefore allelic diversity of these genetic markers cannot be compared directly.

Attempts to model the evolution of genome size typically involve a tendency for the mutational process of small insertions and deletions (indels) to be biased towards deletions (deletion bias) that progressively eliminate nonessential portions of the genome.

However, the mutational spectra of each gene were clearly different, suggesting that more than one mechanism could be involved in the mutational process of each gene.

Further, we provide a systematic computational framework that can be used for accurately deciphering signatures of mutational processes from mutational catalogs of cancer genomes.

For example, accurately deconvoluting signatures of 15 mutational processes from the mutational catalogs of only ten cancer genomes is ineffective.

For example, a mutational process could cause 1,000 mutations in one cancer genome while causing 20,000 in another.

Alexandrov's work is focused on understanding the mutational processes responsible for human cancer and human aging.

The main mutational processes responsible for the variability in microsatellites are considered to be replication-slippage and recombination [ 3].