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In general, our genotyping results were consistent with the documented mutational prevalence for oncogenes, but we observed lower than expected mutational frequencies for tumour suppressors (Supporting Information Table S3).
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For example, determining mutation prevalence (for a range of specific mutations, as well as mutational frequency of any single gene), or the frequency at which any particular gene leads to any single phenotype, remains to be defined for most diseases.
Thus majority of the V3 sequences of HIV-1 Indian isolates were predicted as R5-tropism and we identified few mutational prevalence like for R5-predicted viruses -E25D, Y21F and for X4-predicted viruses E25KRQ, I12, H34Y.
In addition, genes imperative for therapy decision including HER2 (mutation in 1.5 % of samples) and ESR1 (mutation in 0.6 % of samples) show a very low mutational prevalence.
In calculating the optimal parameter values, we also assumed that mutational prevalence was 0 when microsatellite length was 1.
The mutation prevalence in these regions was 2,75- and 3,53-fold more frequent than the average mutational rates along the ABCC6 transporter.
Sequencing of the UV-induced lacZ′ mutants provided mutation spectra and mutational hot spots for the various UV regions.
To show mutational analysis for 11β-hydroxylase deficiency (11β-OHD).
The landscape also clarified a mutational basis for RB and p53 pathway deregulation in this malignancy.
Here, in a designed system, we examine the mutational requirements for transitioning between folds and functions.
To show mutational analysis for androgen insensitivity syndrome (AIS -associated mAIS -associatedphroditismalepseudohermaphroditism
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