Sentence examples for mutational loss of from inspiring English sources

Akt can also be activated via other receptors, and also by Ras activation, mutational loss of PTEN or activating mutation of Akt itself, all of which could lead to translocation of p27 and growth stimulation.

Palomero, T. et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

While the minimal VP5 promoter includes only an Sp1 site at −48, a TATA box at −30, and an initiator (Inr) element at the cap site, here we show that elements upstream of −48 can functionally compensate for the mutational loss of the critical Sp1 site at −48.

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.

Notch signaling and the PI3K-AKT pathway synergize in vivo in a Drosophila melanogaster model of Notch-induced tumorigenesis, and mutational loss of PTEN is associated with human T-ALL resistance to pharmacological inhibition of NOTCH1.

Palomero, T, Sulis, ML, Cortina, M, Real, PJ, Barnes, K, Ciofani, M, Caparros, E, Buteau, J, Brown, K, Perkins, SL, Bhagat, G, Agarwal, AM, Basso, G, Castillo, M, Nagase, S, Cordon-Cardo, C, Parsons, R, Zúñiga-Pflücker, JC, Dominguez, M, and Ferrando, AA. "Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia". Nat Med 13, no. 10 (October 2007): 1203-1210.

This was explained by the paucity of Cys residues in C3 compared to those of the Cys-rich CFH, CFI and MCP structures, thus making the C3 structure less vulnerable to mutational losses of its Cys residues.

The Y-linked copy of the locus is thus subject to mutational loss due to background selection and/or Muller's ratchet on the Y.

Alternatively, we may assume that the replication rates of the different replicator types are renormalized to account for the mutational loss into non-functional RNA forms.

Additionally, although not observed in mutational studies, loss of the tumor suppressor phosphatase and tensin homology (PTEN) appears to be a mechanism by which non-canonical TGFβ/Akt1/NFκβ activation manifests in an animal model [85].

In order to investigate its role in the progression of colorectal cancer, we analysed 22 liver metastases of this malignancy with respect to mutational changes, loss of heterozygosity and expression levels of nm23-H1.