Sentence examples for mutational loads of from inspiring English sources

Finally, the design efficiency and the optimal mutational loads of libraries are assessed by comparing targeted mutational libraries versus libraries of random mutations.

Melanomas have the highest mutational loads of all cancers (Alexandrov et al, 2013).

The nature of multiple plastomes allows for highly efficient gene conversion in asexual genetic systems, correcting mutations and reducing the mutational load of plastomes (Khakhlova and Bock 2006).

Homologous recombination is important in asexual single-celled microorganisms because it counters a build up of mutational load of slightly deleterious mutations: this is termed "Muller's Ratchet" 39, 40.

Together, these sequences increase the mutational load of intron-containing genes because mutations in any of the required splicing signals can lead to nonfunctionalization of the locus.

To better identify candidate mutations for let-504, we first analyzed the general mutational load of KR772.

We found that the predisposing germline mutation of the NF1 gene was frequently converted to homozygosity and the somatic mutational load of NF1-glioma was influenced by age and grade.

We present a point mutation classification method that contrasts SNP databases and has the potential to illuminate the relative mutational load of genes caused by codon bias.

Since melanoma and lung cancer have the highest average mutational load of all tumor types36, this phenomenon probably reflects an increased likelihood of forming neoantigens that will elicit T-cell reactivity, thereby explaining why unselected melanomas also show the highest clinical response rates following current checkpoint-immunotherapy37checkpoint-immunotherapy37

When this happens, the ratchet clicks [12] irreversibly increasing the overall mutational load of the population.

Our interpretation is that as the host/p-endosymbiont association ages, and the mutational load of p-endosymbionts increases, the role of selection increases and slows the rate of accumulation of slightly deleterious mutations.