Sentence examples for mutational load of from inspiring English sources

The nature of multiple plastomes allows for highly efficient gene conversion in asexual genetic systems, correcting mutations and reducing the mutational load of plastomes (Khakhlova and Bock 2006).

Homologous recombination is important in asexual single-celled microorganisms because it counters a build up of mutational load of slightly deleterious mutations: this is termed "Muller's Ratchet" 39, 40.

Together, these sequences increase the mutational load of intron-containing genes because mutations in any of the required splicing signals can lead to nonfunctionalization of the locus.

To better identify candidate mutations for let-504, we first analyzed the general mutational load of KR772.

We present a point mutation classification method that contrasts SNP databases and has the potential to illuminate the relative mutational load of genes caused by codon bias.

When this happens, the ratchet clicks [12] irreversibly increasing the overall mutational load of the population.

Finally, the design efficiency and the optimal mutational loads of libraries are assessed by comparing targeted mutational libraries versus libraries of random mutations.

Melanomas have the highest mutational loads of all cancers (Alexandrov et al, 2013).

Genetic studies of mutational loading of cardiac developmental pathways in the mouse model suggest limits to the buffering capacity of regulatory networks.

The molecular genetic components contributing to idiopathic CHD may include accumulation of multiple rare genomic and epigenetic variants converging to dysregulate cardiac developmental genes leading to mutational loading of developmental networks [ 3].

We used a semi-quantitative analysis that incorporated both the presence and clonality of all tested LOH mutations to provide an assessment of mutational load for a given microdissected target.